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Today is May 6 2016

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   I.
Today's Holidays and Historical Events (updated daily)
Today's Food Holiday
  • National Crepe Suzette Day: More
    From Wikipedia: 'Crêpe Suzette is a French dessert consisting of a crêpe with beurre Suzette, a sauce of caramelized sugar and butter, tangerine or orange juice, zest, and Grand Marnier or orange Curaçao liqueur on top, served flambé.'

    'The most common way to make Crêpe Suzette is to pour liqueur (usually Grand Marnier) over a freshly-cooked crêpe with sugar and ignite it. This will make the alcohol in the liqueur evaporate, resulting in a fairly thick, caramelised sauce. In a restaurant, a Crêpe Suzette is often prepared on a gueridon in front of the guests.'

    'The origin of the dish and its name is disputed. One claim is that it was created from a mistake made by a fourteen-year-old assistant waiter Henri Charpentier in 1895 at the Maitre at Monte Carlo's Café de Paris. He was preparing a dessert for the Prince of Wales, the future King Edward VII of the United Kingdom, whose guests included a beautiful French girl named Suzette. This story was told by Charpentier himself in Life à la Henri, his autobiography, although later contradicted by the Larousse Gastronomique

    Different sources (like the Larousse Gastronomique) however doubt that Charpentier, rather than the head waiter, was serving the prince, because he would have been too young. A less fantastical version emerges from Elsie Lee's interview with him in the 1950s. There, Charpentier explained at length that his complicated version began as the dish of pancakes with fruit sauce his foster mother made on very special occasions. The addition of liqueur was au courant among chefs in Paris at the time.

    The other claim states that the dish was named in honour of French actress Suzanne Reichenberg (1853–1924), who worked professionally under the name Suzette. In 1897, Reichenberg appeared in the Comédie Française in the role of a maid, during which she served crêpes on stage. Monsieur Joseph, owner of Restaurant Marivaux, provided the crêpes. He decided to flambé the thin pancakes to attract the audience's attention and keep the food warm for the actors consuming them. Joseph was subsequently director of the Paillard Restaurant in Paris and was later with the Savoy Hotel in London'.
  • National Beverage Day: More
Other celebrations/observances today:
  • National Space Day / International Space Day: More
    An education and public outreach initiative that takes place annually on the first Friday of May.
    - At LockheedMartin: More
  • Toad Suck Daze: More
    First full weekend of May. May 6-8 in 2016.
    From Wikipedia: 'Toad Suck Daze is an annual community music, arts, and food festival in Conway, Arkansas. It takes place every year in downtown Conway and has been celebrated for over 30 years.

    The Toad Suck Daze festival attracts an estimated 160,000 visitors each year. Notable attractions at the event include music, arts and crafts, a variety of food, carnival rides, and toad races. For these races, visitors enter toads that they have brought from home or that were bred in the community for this purpose. years, the Toad Suck Daze committee has given over US$1 million in scholarships and toward scholarship endowments.

    The legend behind Toad Suck refers to the time when steamboats traveled the Arkansas River. When the water was not deep enough, the steamboats tied up where the Toad Suck Ferry Lock and Dam now spans the river near Conway. While captain and crew waited, they loitered over refreshments at the local tavern. People living nearby commented, "They suck on the bottle 'til they swell up like toads"'.
  • Military Spouse Appreciation Day in the USA: More
    From Wikipedia: 'Military Spouse Day or Military Spouse Appreciation Day is celebrated on the Friday before Mother’s Day in the United States. Many United States citizens take this day to acknowledge the significant contributions, support, and sacrifices of spouses of their Armed Forces.

    President Ronald Reagan recognized the profound importance of spouse commitment to the readiness and well-being of military members and declared May 23, 1984 the first Military Spouse Day with Proclamation 5184, dated April 17, 1984. The US Secretary of Defense, Caspar Weinberger standardized the date by declaring the Friday preceding Mother’s Day as Military Spouse Day.

    Each year, the US President normally commemorates this day with a ceremonial speech and proclamation'.
  • International Tuba Day: More
    A focus on the stereotyped attitudes among people towards tubists and their role in a musical organization.
Awareness / Observance Days on: May 6
  • Health
    • National Nurses Week (May 6-12),
      -- National Nurses Day / National National RN Recognition Day(First day of National Nurses Week),
      -- National School Nurse day (Wednesday of School Nurses Week),
      -- National Student Nurses Day (May 8),
      -- International Nurses Day (May 12 Florence Nightingale' birthday May 12 1820),
      From Wikipedia: 'In the U.S., National Nurses Week was first observed from October 11–16, 1954 in honor of the 100th anniversary of Florence Nightingale's mission to Crimea. President Nixon later proclaimed a 'National Nurse Week' in 1974. In 1982, President Reagan signed a proposal officially designating May 6 as 'National Recognition Day for Nurses,' now known as National Nurses Day or National RN Recognition Day. I
      In 1990, the American Nurses Association (ANA) expanded the holiday into the current National Nurses Week celebrated from 6 May to 12 May.': More
    • International No Diet Day: More
      It began in 1992 in the UK. Concerns reasonable expectations of one's own body and the concept of diet.
    • Child Care Provider Day: More
    • Belonging: National Day to End Bullying: More
      Sponsored by the Boys and Girls Clubs across Canada.
    • National Amyloidosis Day: More
      In Australia.
      From Wikipedia: 'Amyloidosis is a rare disease that results from the buildup of misfolded proteins known as amyloids. When proteins that are normally dissolvable in water fold to become amyloids, they become insoluble and deposit in organs or tissues, disrupting normal function. The type of protein that is misfolded and the organ or tissue in which the misfolded proteins are deposited determine the clinical manifestations of amyloidosis. There are four main types of amyloidosis, each due to the deposition of a specific protein. The most common type is AL amyloidosis, caused by the deposition of light chain proteins produced by plasma cells in different disease states. The second most common is AA amyloidosis due to the accumulation of S amyloid A protein or SAA, which occurs in association with chronic infections - e.g. tuberculosis - or inflammatory illnesses such as rheumatoid arthritis. The third and the fourth type are due to the deposition of a genetically defective or normal form of a protein called transthyretin respectively. Other minor forms of amyloid are also known.

      The presentation of amyloidosis is broad and depends on the site of amyloid accumulation. The kidney and heart are the most common organs involved.

      The cells in the body have two different ways of making proteins. Some proteins are made of one single piece or sequence of aminoacids; in other cases protein fragments are produced, and the fragments come and join together to form the whole protein. But such a protein can sometimes fall apart into the original protein fragments. This process of "flip flopping" happens frequently for certain protein types, especially the ones that cause amyloidosis.

      Treatment depends on the type of amyloidosis that is present. Treatment with high dose melphalan, a chemotherapy agent, followed by stem cell transplantation has showed promise in early studies and is recommended for stage I and II AL amyloidosis. However, only 20-25% of people are eligible for stem cell transplant. Chemotherapy and steroids, with melphalan plus dexamethasone, is mainstay treatment in AL people not eligible for transplant.

      In AA, symptoms may improve if the underlying condition is treated; eprodisate has been shown to slow renal impairment by inhibiting polymerization of amyloid fibrils.

      In ATTR, liver transplant is curative therapy because mutated transthyretin which forms amyloids is produced in the liver.

      People affected by amyloidosis are supported by multiple organizations, i ncluding the Amyloidosis Foundation, Amyloidosis Support Groups Inc., and Amyloidosis Australia, Inc'.
    • Wishbone Day (Global): More
      From the web site: 'Wishbone Day is an international community awareness effort for Osteogenesis Imperfecta (OI), also known as 'brittle bones'. The event color is yellow.'
      From Wikipedia: 'Osteogenesis imperfecta (OI), also known as brittle bone disease or Lobstein syndrome, is a congenital bone disorder characterized by brittle bones that are prone to fracture. OI may also present with shorter height, neurological features including communicating hydrocephalus, basilar invagination, and seizures, blue sclerae, hearing loss, or other complications. The fractures themselves can cause acute or chronic pain, reduced quality of life, and depression.

      People with OI are born with defective connective tissue, or without the ability to make it, usually because of a deficiency of type I collagen. Eight types of OI can be distinguished. Most cases are caused by mutations in the COL1A1 and COL1A2 genes, both of which code for type I collagen. Diagnosis of OI is based on the clinical features and may be confirmed by collagen or DNA testing.

      There is no cure for OI. Treatment is aimed at increasing overall bone strength to prevent fracture and maintain mobility. Treatment includes bisphosphonates, surgery, physical therapy, and physical aids.
  • Other
    • National Public Gardens Day: More
      From Wikipedia: 'National Public Gardens Day, occurring annually on the Friday before Mother's Day, is a day to promote awareness of botanic gardens, arboreta, zoos, historic gardens, or any of North America's public gardens. The day was established by the American Public Gardens Association, a Pennsylvania non-profit organization that supports, resources and promotes public gardens in North America, in partnership with their sponsor, Rain Bird. The national spokesperson for National Public Gardens Day is Paul James, host of HGTV's Gardening By The Yard'.
    • National Tourist Appreciation Day: More
      During National Travel and Tourism Week (May 5 - 13. In 32 of the U.S. states, tourism is second only to healthcare as the top business employer..
Events in the past on: May 6
  • In 1889, The Eiffel Tower was officially opened to the public at the Universal Exposition in Paris.
    From Wikipedia: 'The Eiffel Tower (French: Tour Eiffel, is a wrought iron lattice tower on the Champ de Mars in Paris, France. It is named after the engineer Gustave Eiffel, whose company designed and built the tower.

    Constructed in 1889 as the entrance to the 1889 World's Fair, it was initially criticized by some of France's leading artists and intellectuals for its design, but it has become a global cultural icon of France and one of the most recognisable structures in the world. The Eiffel Tower is the most-visited paid monument in the world; 6.91 million people ascended it in 2015.

    The tower is 324 metres (1,063 ft) tall, about the same height as an 81-storey building, and the tallest structure in Paris. Its base is square, measuring 125 metres (410 ft) on each side. During its construction, the Eiffel Tower surpassed the Washington Monument to b ecome the tallest man-made structure in the world, a title it held for 41 years until the Chrysler Building in New York City was finished in 1930.

    Due to the addition of a broadcasting aerial at the top of the tower in 1957, it is now taller than the Chrysler Building by 5.2 metres (17 ft). Excluding transmitters, the Eiffel Tower is the second-tallest structure in France after the Millau Viaduct.

    The main structural work was completed at the end of March 1889 and, on 31 March, Eiffel celebrated by leading a group of government officials, accompanied by representatives of the press, to the top of the tower. Because the lifts were not yet in operation, the ascent was made by foot, and took over an hour, with Eiffel stopping frequently to explain various features. Most of the party chose to stop at the lower levels, but a few, including the structural engineer, Émile Nouguier, the head of construction, Jean Compagnon, the President of the City Council, and reporters from Le Figaro and Le Monde Illustré, completed the ascent. At 2:35 pm, Eiffel hoisted a large Tricolour to the accompaniment of a 25-gun salute fired at the first level.

    There was still work to be done, particularly on the lifts and facilities, and the tower was not opened to the public until nine days after the opening of the exposition on 6 May; even then, the lifts had not been completed. The tower was an instant success with the public, and nearly 30,000 visitors made the 1,710-step climb to the top before the lifts entered service on 26 May. Tickets cost 2 francs for the first level, 3 for the second, and 5 for the top, with half-price admission on Sundays, and by the end of the exhibition there had been 1,896,987 visitors'.
    - At FamousDaily: More
    - At Wikipedia: More
    - On YouTube: More
    - On YouTube: Moren
  • In 1937, The German zeppelin Hindenburg catches fire and is destroyed within a minute while attempting to dock at Lakehurst, New Jersey. Thirty-six people are killed.
    From Wikipedia: 'The Hindenburg disaster occurred on May 6, 1937, as the German passenger airship LZ 129 Hindenburg caught fire and was destroyed during its attempt to dock with its mooring mast at Naval Air Station Lakehurst in Manchester Township, New Jersey, United States. Of the 97 people on board (36 passengers and 61 crewmen), there were 35 fatalities (13 passengers and 22 crewmen). One worker on the ground was also killed, making a total of 36 fatalities.

    The disaster was the subject of spectacular newsreel coverage, photographs, and Herbert Morrison's recorded radio eyewitness reports from the landing field, which were broadcast the next day. A variety of hypotheses have been put forward for both the cause of ignition and the initial fuel for the ensuing fire. The incident shattered public confidence in the giant, passenger-carrying rigid airship and marked the abrupt end of the airship era.
    - At Wikipedia: More
    - On YouTube: More
    - On YouTube: Moren
  • In 1941, At California's March Field, Bob Hope performs his first USO show.
    From Wikipedia: 'Leslie Townes "Bob" Hope, KBE, KC*SG, KSS (May 29, 1903 – July 27, 2003), was an British-American comedian, vaudevillian, actor, singer, dancer, athlete, and author. With a career spanning nearly 80 years, Hope appeared in over 70 films and shorts, including a series of "Road" movies also starring Bing Crosby and Dorothy Lamour. In addition to hosting the Academy Awards 19 times (more than any other host), he appeared in many stage productions and television roles and was the author of fourteen books. The song "Thanks for the Memory" is widely regarded as Hope's signature tune.

    Hope participated in the sports of golf and boxing, and owned a small stake in his hometown baseball team, the Cleveland Indians. He was married to performer Dolores Hope (née DeFina) for 69 years. Hope died at age 100 at his home in Toluca Lake, California.

    'While aboard the RMS Queen Mary when World War II began in September 1939, Hope volunteered to perform a special show for the passengers, during which he sang "Thanks for the Memory" with rewritten lyrics. He performed his first USO show on May 6, 1941, at March Field, California, and continued to travel and entertain troops for the rest of World War II, later during the Korean War, the Vietnam War, the third phase of the Lebanon Civil War, the latter years of the Iran–Iraq War, and the 1990–91 Persian Gulf War. His USO career lasted half a century, during which he headlined 57 tours. He had a deep respect for the men and women who served in the military, and this was reflected in his willingness to go anywhere in order to entertain them. During the Vietnam War, Hope had trouble convincing some performers to join him on tour. Anti-war sentiment was high, and Hope's pro-troop stance made him a target of criticism. Some shows were drowned out by boos and others were listened to in silence. The tours were funded by the United States Department of Defense, his television sponsors, and by NBC, the network which broadcast the television specials that were created after each tour.
    - At Wikipedia: More
    - On YouTube: Moren
  • In 1954, Roger Bannister becomes the first person to run the mile in under four minutes. The time was 3 min 59.4 sec.
    From Wikipedia: 'Sir Roger Gilbert Bannister, CBE (born 23 March 1929) is an English former middle-distance athlete, physician and academic, who ran the first sub-four-minute mile.

    In the 1952 Olympics in Helsinki, Bannister set a British record in the 1500 metres but finished fourth. This strengthened his resolve to be the first 4-minute miler.

    He achieved this feat on 6 May 1954 at Iffley Road track in Oxford, with Chris Chataway and Chris Brasher providing the pacing. When the announcer declared "The time was three...", the cheers of the crowd drowned out Bannister's exact time, which was 3 min 59.4 se Bannister's record lasted just 46 days. He had reached this record with minimal training, while practising as a junior doctor.
    - At Wikipedia: More
    - On YouTube: More
  • In 1957, The television show 'I Love Lucy' has it's last show on CBS after running 6 years.
    From Wikipedia: 'I Love Lucy is an American television sitcom starring Lucille Ball, Desi Arnaz, Vivian Vance, and William Frawley. The black-and-white series originally ran from October 15, 1951, to May 6, 1957, on CBS. After the series ended in 1957, however, a modified version continued for three more seasons with 13 one-hour specials, running from 1957 to 1960, known first as The Lucille Ball-Desi Arnaz Show and later in reruns as The Lucy–Desi Comedy Hour.

    I Love Lucy was the most watched show in the United States in four of its six seasons, and was the first to end its run at the top of the Nielsen ratings (an accomplishment later matched only by The Andy Griffith Show in 1968 and Seinfeld in 1998). The show is still syndicated in dozens of languages across the world and remains popular with an American audience of 40 million each year. A colorized version of its Christmas episode attracted more than 8 million viewers when CBS aired it in prime time in 2013 – 62 years after the show premiered. A second colorized special, featuring the "L.A. At Last!" and "Lucy and Superman" episodes, aired on May 17, 2015, attracting 6.4 million viewers.

    I Love Lucy is often regarded as one of the greatest and most influential sitcoms in history. In 2012, it was voted the 'Best TV Show of All Time' in a survey conducted by ABC News and People Magazine'.
    - At FamousDaily: More
    - At Wikipedia: More
    - On YouTube: More
    - On YouTube (Superman): More
    - On YouTube (Chocolate Factory): More
    - On YouTube (Vitameatavegamin): More
    - On YouTube: Moren
  • In 1994, The opening of the Channel Tunnel.
    From Wikipedia: The Channel Tunnel, mocknamed and shortened to Chunnel) is a 50.5-kilometre (31.4 mi) rail tunnel linking Folkestone, Kent, in the United Kingdom, with Coquelles, Pas-de-Calais, near Calais in northern France, beneath the English Channel at the Strait of Dover. At its lowest point, it is 75 m (250 ft) deep. At 37.9 kilometres (23.5 mi), the tunnel has the longest undersea portion of any tunnel in the world, although the Seikan Tunnel in Japan is both longer overall at 53.85 kilometres (33.46 mi) and deeper at 240 metres (790 ft) below sea level. The speed limit in the tunnel is 160 kilometres per hour (99 mph).

    The tunnel carries high-speed Eurostar passenger trains, the Eurotunnel Shuttle for road vehicles—the largest such transport in the world—and international freight trains. The tunnel connects end-to-end with the LGV Nord and High Speed 1 high-speed railway lines.

    Working from both the English side and the French side of the Channel, eleven tunnel boring machines or TBMs cut through chalk marl to construct two rail tunnels and a service tunnel. The vehicle shuttle terminals are at Cheriton (part of Folkestone) and Coquelles, and are connected to the English M20 and French A16 motorwaysrespectively.
    - At Wikipedia:More
    - On YouTube: Moren
  • In 2004, The final episode of Friends airs on NBC.
    From Wikipedia: Friends is an American television sitcom, created by David Crane and Marta Kauffman, which originally aired on NBC from September 22, 1994, to May 6, 2004, lasting ten seasons. With an ensemble cast starring Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc, Matthew Perry and David Schwimmer, the show revolves around six friends living in Manhattan. The series was produced by Bright/Kauffman/Crane Productions, in association with Warner Bros. Television. The original executive producers were Kevin S. Bright, Marta Kauffman, and David Crane.

    Kauffman and Crane began developing Friends under the title Insomnia Cafe between November and December 1993. They presented the idea to Bright, and together they pitched a seven-page treatment of the show to NBC. After several script rewrites and changes, including a second title change to Friends Like Us, the series was finally named Friends.

    Friends ranked no. 24 on the Writers Guild of America's 101 Best Written TV Series of All Time and no. 28 on TV Guide's 60 Best TV Series of All Time. In 2014, the series was ranked by Mundo Estranho the Best TV Series of All Time'.
    - FamousDaily: More
    - At Wikipedia: More
    - On YouTube: Moren
  II.
Henry's Heads Up! - previous days social media post (updated daily)

Tomorrow's food holidays:
- 'National Crepe Suzette Day'. From Wikipedia: 'Crêpe Suzette is a French dessert consisting of a crêpe with beurre Suzette, a sauce of caramelized sugar and butter, tangerine or orange juice, zest, and Grand Marnier or orange Curaçao liqueur on top, served flambé.'

'The most common way to make Crêpe Suzette is to pour liqueur (usually Grand Marnier) over a freshly-cooked crêpe with sugar and ignite it. This will make the alcohol in the liqueur evaporate, resulting in a fairly thick, caramelised sauce. in a restaurant, a Crêpe Suzette is often prepared on a gueridon in front of the guests.'

'The origin of the dish and its name is disputed. One claim is that it was created from a mistake made by a fourteen-year-old assistant waiter Henri Charpentier in 1895 at the Maitre at Monte Carlo's Café de Paris. He was preparing a dessert for the Prince of Wales, the future King Edward VII of the United Kingdom, whose guests included a beautiful French girl named Suzette. This story was told by Charpentier himself in Life à la Henri, his autobiography, although later contradicted by the Larousse Gastronomique

Different sources (like the Larousse Gastronomique) however doubt that Charpentier, rather than the head waiter, was serving the prince, because he would have been too young. A less fantastical version emerges from Elsie Lee's interview with him in the 1950s. There, Charpentier explained at length that his complicated version began as the dish of pancakes with fruit sauce his foster mother made on very special occasions. The addition of liqueur was au courant among chefs in Paris at the time.

The other claim states that the dish was named in honour of French actress Suzanne Reichenberg (1853–1924), who worked professionally under the name Suzette. in 1897, Reichenberg appeared in the Comédie Française in the role of a maid, during which she served crêpes on stage. Monsieur Joseph, owner of Restaurant Marivaux, provided the crêpes. He decided to flambé the thin pancakes to attract the audience's attention and keep the food warm for the actors consuming them. Joseph was subsequently director of the Paillard Restaurant in Paris and was later with the Savoy Hotel in London'.
[The Hankster says] in Texas we call the flapjacks, and they aren't skinny either. The only thing we put on them is maple syrup and butter, and then only if we are not going to roll them up and run with them as finger food.


- 'National Beverage Day'.
[The Hankster says] I'll choose a tall glass of cold milk with my Crepes.


Other celebrations/observances tomorrow:

- 'National Space Day / International Space Day''. An education and public outreach initiative that takes place annually on the first Friday of May.

- Toad Suck Daze'. First full weekend of May. May 6-8 in 2016. From Wikipedia: 'Toad Suck Daze is an annual community music, arts, and food festival in Conway, Arkansas. It takes place every year in downtown Conway and has been celebrated for over 30 years.

The Toad Suck Daze festival attracts an estimated 160,000 visitors each year. Notable attractions at the event include music, arts and crafts, a variety of food, carnival rides, and toad races. For these races, visitors enter toads that they have brought from home or that were bred in the community for this purpose. years, the Toad Suck Daze committee has given over US$1 million in scholarships and toward scholarship endowments.

The legend behind Toad Suck refers to the time when steamboats traveled the Arkansas River. When the water was not deep enough, the steamboats tied up where the Toad Suck Ferry Lock and Dam now spans the river near Conway. While captain and crew waited, they loitered over refreshments at the local tavern. People living nearby commented, "They suck on the bottle 'til they swell up like toads"'.
[The Hankster says] See, I didn't make this one up. Someone beat me to it.

- 'Military Spouse Appreciation Day in the USA'. From Wikipedia: 'Military Spouse Day or Military Spouse Appreciation Day is celebrated on the Friday before Mother’s Day in the United States. Many United States citizens take this day to acknowledge the significant contributions, support, and sacrifices of spouses of their Armed Forces.

President Ronald Reagan recognized the profound importance of spouse commitment to the readiness and well-being of military members and declared May 23, 1984 the first Military Spouse Day with Proclamation 5184, dated April 17, 1984. The US Secretary of Defense, Caspar Weinberger standardized the date by declaring the Friday preceding Mother’s Day as Military Spouse Day.

Each year, the US President normally commemorates this day with a ceremonial speech and proclamation'.

- 'International Tuba Day'. A focus on the stereotyped attitudes among people towards tubists and their role in a musical organization.
[The Hankster says] I respect the instrument and the players. I don't think I would look good waring one, as s spring hat.


Awareness / Observance Days on: May 6
o Health
- 'National Nurses Week (May 6-12),
-- National Nurses Day / National National RN Recognition Day(First day of National Nurses Week),
-- National School Nurse day (Wednesday of School Nurses Week),
-- National Student Nurses Day (May 8),
-- International Nurses Day (May 12 Florence Nightingale' birthday May 12 1820), =
From Wikipedia: 'In the U.S., National Nurses Week was first observed from October 11–16, 1954 in honor of the 100th anniversary of Florence Nightingale's mission to Crimea. President Nixon later proclaimed a 'National Nurse Week' in 1974. In 1982, President Reagan signed a proposal officially designating May 6 as 'National Recognition Day for Nurses,' now known as National Nurses Day or National RN Recognition Day. I

In 1990, the American Nurses Association (ANA) expanded the holiday into the current National Nurses Week celebrated from 6 May to 12 May.'

- 'International No Diet Day'. It began in 1992 in the UK. Concerns reasonable expectations of one's own body and the concept of diet.

- 'Child Care Provider Day'.

- 'Belonging: National Day to End Bullying'. Sponsored by the Boys and Girls Clubs across Canada.

- 'National Amyloidosis Day'. In Australia.
From Wikipedia: 'Amyloidosis is a rare disease that results from the buildup of misfolded proteins known as amyloids. When proteins that are normally dissolvable in water fold to become amyloids, they become insoluble and deposit in organs or tissues, disrupting normal function. The type of protein that is misfolded and the organ or tissue in which the misfolded proteins are deposited determine the clinical manifestations of amyloidosis. There are four main types of amyloidosis, each due to the deposif a specific protein. The most common type is AL amyloidosis, caused by the deposition of light chain proteins produced by plasma cells in different disease states. The second most common is AA amyloidosis due to the accumulation of S amyloid A protein or SAA, which occurs in association with chronic infections - e.g. tuberculosis - or inflammatory illnesses such as rheumatoid arthritis. The third and the fourth type are due to the deposition of a genetically defective or normal form of a protein called transthyretin respectively. Other minor forms of amyloid are also known.

The presentation of amyloidosis is broad and depends on the site of amyloid accumulation. The kidney and heart are the most common organs involved.

The cells in the body have two different ways of making proteins. Some proteins are made of one single piece or sequence of aminoacids; in other cases protein fragments are produced, and the fragments come and join together to form the whole protein. But such a protein can sometimes fall apart into the original protein fragments. This process of "flip flopping" happens frequently for certain protein types, especially the ones that cause amyloidosis.

Treatment depends on the type of amyloidosis that is present. Treatment with high dose melphalan, a chemotherapy agent, followed by stem cell transplantation has showed promise in early studies and is recommended for stage I and II AL amyloidosis. However, only 20-25% of people are eligible for stem cell transplant. Chemotherapy and steroids, with melphalan plus dexamethasone, is mainstay treatment in AL people not eligible for transplant.

In AA, symptoms may improve if the underlying condition is treated; eprodisate has been shown to slow renal impairment by inhibiting polymerization of amyloid fibrils.

In ATTR, liver transplant is curative therapy because mutated transthyretin which forms amyloids is produced in the liver.

People affected by amyloidosis are supported by multiple organizations, i ncluding the Amyloidosis Foundation, Amyloidosis Support Groups Inc., and Amyloidosis Australia, Inc'.

- 'Wishbone Day (Global)'. From the web site: 'Wishbone Day is an international community awareness effort for Osteogenesis Imperfecta (OI), also known as 'brittle bones'. The event color is yellow.'
From Wikipedia: 'Osteogenesis imperfecta (OI), also known as brittle bone disease or Lobstein syndrome, is a congenital bone disorder characterized by brittle bones that are prone to fracture. OI may also present with shorter height, neurological features including communicating hydrocephalus, basilar invagination, and seizures, blue sclerae, hearing loss, or other complications. The fractures themselves can cause acute or chronic pain, reduced quality of life, and depression.

People with OI are born with defective connective tissue, or without the ability to make it, usually because of a deficiency of type I collagen. Eight types of OI can be distinguished. Most cases are caused by mutations in the COL1A1 and COL1A2 genes, both of which code for type I collagen. Diagnosis of OI is based on the clinical features and may be confirmed by collagen or DNA testing.

There is no cure for OI. Treatment is aimed at increasing overall bone strength to prevent fracture and maintain mobility. Treatment includes bisphosphonates, surgery, physical therapy, and physical aids.


o Other
- 'National Public Gardens Day'.
From Wikipedia: 'National Public Gardens Day, occurring annually on the Friday before Mother's Day, is a day to promote awareness of botanic gardens, arboreta, zoos, historic gardens, or any of North America's public gardens. The day was established by the American Public Gardens Association, a Pennsylvania non-profit organization that supports, resources and promotes public gardens in North America, in partnership with their sponsor, Rain Bird. The national spokesperson for National Public Gardens Daaul James, host of HGTV's Gardening By The Yard'.

- 'National Tourist Appreciation Day: During National Travel and Tourism Week (May 5 - 13. In 32 of the U.S. states, tourism is second only to healthcare as the top business employer..


Historical events in the past on: May 6

- In 1889, The Eiffel Tower was officially opened to the public at the Universal Exposition in Paris. From Wikipedia: 'The Eiffel Tower (French: Tour Eiffel, is a wrought iron lattice tower on the Champ de Mars in Paris, France. It is named after the engineer Gustave Eiffel, whose company designed and built the tower.

Constructed in 1889 as the entrance to the 1889 World's Fair, it was initially criticized by some of France's leading artists and intellectuals for its design, but it has become a global cultural icon of France and one of the most recognisable structures in the world. The Eiffel Tower is the most-visited paid monument in the world; 6.91 million people ascended it in 2015.

The tower is 324 metres (1,063 ft) tall, about the same height as an 81-storey building, and the tallest structure in Paris. Its base is square, measuring 125 metres (410 ft) on each side. During its construction, the Eiffel Tower surpassed the Washington Monument to b ecome the tallest man-made structure in the world, a title it held for 41 years until the Chrysler Building in New York City was finished in 1930.

Due to the addition of a broadcasting aerial at the top of the tower in 1957, it is now taller than the Chrysler Building by 5.2 metres (17 ft). Excluding transmitters, the Eiffel Tower is the second-tallest structure in France after the Millau Viaduct.

The main structural work was completed at the end of March 1889 and, on 31 March, Eiffel celebrated by leading a group of government officials, accompanied by representatives of the press, to the top of the tower. Because the lifts were not yet in operation, the ascent was made by foot, and took over an hour, with Eiffel stopping frequently to explain various features. Most of the party chose to stop at the lower levels, but a few, including the structural engineer, Émile Nouguier, the head of construction, Jean Compagnon, the President of the City Council, and reporters from Le Figaro and Le Monde Illustré, completed the ascent. At 2:35 pm, Eiffel hoisted a large Tricolour to the accompaniment of a 25-gun salute fired at the first level.

There was still work to be done, particularly on the lifts and facilities, and the tower was not opened to the public until nine days after the opening of the exposition on 6 May; even then, the lifts had not been completed. The tower was an instant success with the public, and nearly 30,000 visitors made the 1,710-step climb to the top before the lifts entered service on 26 May. Tickets cost 2 francs for the first level, 3 for the second, and 5 for the top, with half-price admission on Sundays, and by theend of the exhibition there had been 1,896,987 visitors'.

- In 1937, The German zeppelin Hindenburg catches fire and is destroyed within a minute while attempting to dock at Lakehurst, New Jersey. Thirty-six people are killed. From Wikipedia: 'The Hindenburg disaster occurred on May 6, 1937, as the German passenger airship LZ 129 Hindenburg caught fire and was destroyed during its attempt to dock with its mooring mast at Naval Air Station Lakehurst in Manchester Township, New Jersey, United States. Of the 97 people on board (36 passengers and 61 crewmen), there were 35 fatalities (13 passengers and 22 crewmen). One worker on the ground was also killed, making a total of 36 fatalities.

The disaster was the subject of spectacular newsreel coverage, photographs, and Herbert Morrison's recorded radio eyewitness reports from the landing field, which were broadcast the next day. A variety of hypotheses have been put forward for both the cause of ignition and the initial fuel for the ensuing fire. The incident shattered public confidence in the giant, passenger-carrying rigid airship and marked the abrupt end of the airship era.

- In 1941, At California's March Field, Bob Hope performs his first USO show. From Wikipedia: 'Leslie Townes "Bob" Hope, KBE, KC*SG, KSS (May 29, 1903 – July 27, 2003), was an British-American comedian, vaudevillian, actor, singer, dancer, athlete, and author. With a career spanning nearly 80 years, Hope appeared in over 70 films and shorts, including a series of "Road" movies also starring Bing Crosby and Dorothy Lamour. In addition to hosting the Academy Awards 19 times (more than any other host), he appeared in many stage productions and television roles and was the author of fourteen books. The song "Thanks for the Memory" is widely regarded as Hope's signature tune.

Hope participated in the sports of golf and boxing, and owned a small stake in his hometown baseball team, the Cleveland Indians. He was married to performer Dolores Hope (née DeFina) for 69 years. Hope died at age 100 at his home in Toluca Lake, California.

'While aboard the RMS Queen Mary when World War II began in September 1939, Hope volunteered to perform a special show for the passengers, during which he sang "Thanks for the Memory" with rewritten lyrics. He performed his first USO show on May 6, 1941, at March Field, California, and continued to travel and entertain troops for the rest of World War II, later during the Korean War, the Vietnam War, the third phase of the Lebanon Civil War, the latter years of the Iran–Iraq War, and the 1990–91 Persian Gulf War. His USO career lasted half a century, during which he headlined 57 tours. He had a deep respect for the men and women who served in the military, and this was reflected in his willingness to go anywhere in order to entertain them. During the Vietnam War, Hope had trouble convincing some performers to join him on tour. Anti-war sentiment was high, and Hope's pro-troop stance made him a target of criticism. Some shows were drowned out by boos and others were listened to in silence. The tours were funded by the United States Department of Defense, his television sponsors, and by NBC, the network which broadcast the television specials that were created after each tour.

- In 1954, Roger Bannister becomes the first person to run the mile in under four minutes. The time was 3 min 59.4 sec. From Wikipedia: 'Sir Roger Gilbert Bannister, CBE (born 23 March 1929) is an English former middle-distance athlete, physician and academic, who ran the first sub-four-minute mile.

In the 1952 Olympics in Helsinki, Bannister set a British record in the 1500 metres but finished fourth. This strengthened his resolve to be the first 4-minute miler.

He achieved this feat on 6 May 1954 at Iffley Road track in Oxford, with Chris Chataway and Chris Brasher providing the pacing. When the announcer declared "The time was three...", the cheers of the crowd drowned out Bannister's exact time, which was 3 min 59.4 se Bannister's record lasted just 46 days. He had reached this record with minimal training, while practising as a junior doctor.

- In 1957, The television show 'I Love Lucy' has it's last show on CBS after running 6 years. From Wikipedia: 'I Love Lucy is an American television sitcom starring Lucille Ball, Desi Arnaz, Vivian Vance, and William Frawley. The black-and-white series originally ran from October 15, 1951, to May 6, 1957, on CBS. After the series ended in 1957, however, a modified version continued for three more seasons with 13 one-hour specials, running from 1957 to 1960, known first as The Lucille Ball-Desi Arnaz Show and later in reruns as The Lucy–Desi Comedy Hour.

I Love Lucy was the most watched show in the United States in four of its six seasons, and was the first to end its run at the top of the Nielsen ratings (an accomplishment later matched only by The Andy Griffith Show in 1968 and Seinfeld in 1998). The show is still syndicated in dozens of languages across the world and remains popular with an American audience of 40 million each year. A colorized version of its Christmas episode attracted more than 8 million viewers when CBS aired it in prime time in 2013– 62 years after the show premiered. A second colorized special, featuring the "L.A. At Last!" and "Lucy and Superman" episodes, aired on May 17, 2015, attracting 6.4 million viewers.

I Love Lucy is often regarded as one of the greatest and most influential sitcoms in history. In 2012, it was voted the 'Best TV Show of All Time' in a survey conducted by ABC News and People Magazine'.

- In 1994, The opening of the Channel Tunnel. From Wikipedia: The Channel Tunnel, mocknamed and shortened to Chunnel) is a 50.5-kilometre (31.4 mi) rail tunnel linking Folkestone, Kent, in the United Kingdom, with Coquelles, Pas-de-Calais, near Calais in northern France, beneath the English Channel at the Strait of Dover. At its lowest point, it is 75 m (250 ft) deep. At 37.9 kilometres (23.5 mi), the tunnel has the longest undersea portion of any tunnel in the world, although the Seikan Tunnel in Japan is both longer overall at 53.85 kilometres (33.46 mi) and deeper at 240 metres (790 ft) below sea level. The speed limit in the tunnel is 160 kilometres per hour (99 mph).

The tunnel carries high-speed Eurostar passenger trains, the Eurotunnel Shuttle for road vehicles—the largest such transport in the world—and international freight trains. The tunnel connects end-to-end with the LGV Nord and High Speed 1 high-speed railway lines.

Working from both the English side and the French side of the Channel, eleven tunnel boring machines or TBMs cut through chalk marl to construct two rail tunnels and a service tunnel. The vehicle shuttle terminals are at Cheriton (part of Folkestone) and Coquelles, and are connected to the English M20 and French A16 motorwaysrespectively.

- In 2004, The final episode of Friends airs on NBC. From Wikipedia: Friends is an American television sitcom, created by David Crane and Marta Kauffman, which originally aired on NBC from September 22, 1994, to May 6, 2004, lasting ten seasons. With an ensemble cast starring Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc, Matthew Perry and David Schwimmer, the show revolves around six friends living in Manhattan. The series was produced by Bright/Kauffman/Crane Productions, in association with Warner Bros. Television. The original executive producers were Kevin S. Bright, Marta Kauffman, and David Crane.

Kauffman and Crane began developing Friends under the title Insomnia Cafe between November and December 1993. They presented the idea to Bright, and together they pitched a seven-page treatment of the show to NBC. After several script rewrites and changes, including a second title change to Friends Like Us, the series was finally named Friends.

Friends ranked no. 24 on the Writers Guild of America's 101 Best Written TV Series of All Time and no. 28 on TV Guide's 60 Best TV Series of All Time. In 2014, the series was ranked by Mundo Estranho the Best TV Series of All Time'.

 III.
Top Song & Movie 50 years ago today (last updated April 30 2016 next May 7 2016

No. 1 song

  • Good Lovin' - Young Rascals
    On YouTube: More
    At Wikipedia: More
    '(You're My) Soul And Inspiration' has been displaced by 'Good Lovin'', which will hold the no. 1 spot until May 7 1966, when 'Monday, Monday - The Mamas and the Papas', takes over.From Wikipedia: "Good Lovin'" is a song written by Rudy Clark and Arthur Resnick that was a number one hit single for The Young Rascals in 1966.'

    'The tale is told that Rascal Felix Cavaliere heard it on a New York City radio station and the group added it to their concert repertoire. Co-producer Tom Dowd captured this live feel on the recording, even though the group did not think the performance held together well. "Good Lovin'" rose to the top of the Billboard Pop Singles chart in the spring of 1966 and represented the Young Rascals' first real hit'.

Top movie

  • Doctor Zhivago (once again)
    At Wikipedia:  More
    On IMDb: More
    On YouTube (trailer): More
    Having displaced 'The Singing Nun', it will be there until the weekend box office of May 29 1966 when, 'The Russians Are Coming, the Russians Are Coming', takes over.
    From Wikipedia: 'Doctor Zhivago is a 1965 British-Russian-American epic romantic drama film directed by David Lean and starring Omar Sharif and Julie Christie. It is set in Russia between the years prior to World War I and the Russian Civil War of 1917–1922, and is based on the Boris Pasternak novel of the same name. While immensely popular in the West, the book was banned in the Soviet Union for decades. For this reason, the film could not be made in the Soviet Union and was instead filmed mostly in Spain'.
  IV.
Today in the Past (reference sites): May 6
   V.
This month May 2016 (updated once a month - last updated - May 6 2016)

Monthly holiday / awareness days in May

Food
Aramanth Month - Grain of the month
Gifts From The Garden Month
International Mediterranean Diet Month
National Barbeque Month
National Egg Month
National Hamburger Month
National Mediterranean Diet Month
National Salad Month
National Salsa Month
National Sweet Vidalia Onions Month
National Vinegar Month

Health
ALS Awareness Month - (Amyotrophic Lateral Sclerosis or Lou Gehrig's Disease)
APS Awareness Month - Antiphospholipid Antibody Syndrome
Arthritis Awareness Month
Asthma Awareness Month
Better Hearing and Speech Month
Borderline Personality Disorder Month
Brain Tumor Awareness Month
Celiac Awareness Month
Cystic Fibrosis Awareness Month
EDS (Ehlers-Danlos Syndrome) Awareness Month
Family Wellness Month
Fibromyalgia Education and Awareness Month
Food Allergy Action Month
Global Health and Fitness Month
Heal the Children Month
Healthy Vision Month
Huntington's Disease Awareness Month
Lupus Awareness Month
Melanoma/Skin Cancer Detection and Prevention Month
National Allergy/Asthma Awareness Month
National Better Hearing Month
National Hepatitis Awareness Month
National High Blood Pressure Education Month
National Meditation Month
National Mental Health Month
National Osteoporosis Prevention Month
National Physical Fitness and Sports Month
National Physiotherapy Month
National Stroke Awareness Month
National Toddler Immunization Month
National Tuberous Sclerosis Month
National Water Safety Month
National Youth Traffic Safety Month
Neurofibromatosis Awareness Month
Neurofibromatosis Awareness Month
Prader-Willi Syndrome Awareness Month
Preeclampsia Awareness Month
Skin Cancer Awareness Month
Spiritual Literacy Month
Strike Out Strokes Month
Tay-Sachs and Canavan Diseases Month
Tourettes Syndrome Awareness Month
Toxic Encephalopathy and Chemical Injury Awareness Month
Ultra-violet Awareness Month
Women's Health Care Month
World Lyme Disease Awareness Month

Animal / Pet
Chip Your Pet Month
Gardening for Wildlife Month
Go Fetch! Food Drive for Homeless Animals Month
National Guide Dog Month
National Pet Month
National Service Dog Eye Examination Month
Pet Cancer Awareness Month

Other
American Wetlands Month
Asian American and Pacific Islander Heritage Month
Building Safety Month
Clean Air Month
Creative Beginnings Month
Family Reunion Month
Get Caught Reading Month
Global Civility Awareness Month
Golf Month
Haitian Heritage Month
Home Schooling Awareness Month
International Audit Month
International Business Image Improvement Month
International Victorious Woman Month
Jewish-American Heritage Month
Latino Books Month
Motorcycle Safety Month
Mystery Month
National Bike Month
National Foster Care Month
National Good Car Keeping Month
National Inventors Month
National Photo Month
National Smile Month
Personal History Month
Social Security Education Awareness Month
Tennis Month
Textile Month
Young Achievers of Tomorrow Month


May is:

May origin (from Wikipedia):
The month May was named for the Greek goddess Maia, who was identified with the Roman era goddess of fertility, Bona Dea, whose festival was held in May. Conversely, the Roman poet Ovid provides a second etymology, in which he says that the month of May is named for the maiores, Latin for 'elders,' and that the following month (June) is named for the iuniores, or 'young people'

May ' is the fifth month of the year in the Julian and Gregorian Calendars and one of seven months with the length of 31 days.
May is a month of Autumn in the Southern Hemisphere and spring in the Northern Hemisphere (Summer in Europe). Therefore May in the Southern Hemisphere is the seasonal equivalent of November in the Northern Hemisphere and vice versa. '

May at Wikipedia: More

  VI.
TV fifty years ago 1966 (updated yearly - last updated Jan. 1 2016)

If you couldn't afford 90 cents for a movie ticket, 50 years ago, or your 45 RPM record player was broke, you might watch one of these shows on TV.
From this Wikipedia article: More

 VII.
Best selling books fifty years ago (updated yearly - last updated Jan. 1 2016)

Best selling books of 1966 More

VIII.
Fun (Last link added October 1 2014, but content on each site may change daily)
  • Astronomy Picture of the Day: More
  • NOAA: - National Hurricane Center - Atlantic Graphical Tropical Weather Outlook: More
  • Listen to Old Radio Shows: (streaming mp3 with schedule) More
  • NASA TV: (video feed) More
    NASA TV schedule: More
  • Public Domain eBook Links

    Sites for downloading or reading free Public Domain eBooks. Available in various formats. More

  • Podcast: A Moment of Science. Approximately 1 minute general science facts.
    Home page: More
    RSS: More
  • Podcast: The Naked Scientists. Current science, medicine, space and other science
    Home page: More
    RSS: More
  • Podcast: Quirks & Quarks. Current science news.
    Home page: More
    RSS: More
  • Articles and videos: Universe Today. Current space and astronomy news.
    Home page: More
    RSS: More
  • Old Picture of the Day - "Each day we bring you one stunning little glimpse of history in the form of a historical photograph."
    Home page: More
    RSS: More
  IX.
Other Holiday Sites (Last link added October 1 2014. Link content changes yearly)

Below, are listed several holiday sites that I reference in addition to other holiday researches.


US Government Holidays

  • 2016 Postal Holidays More
  • 2016 Official Federal Holidays More

Holidays Worldwide

  • List of holidays by country More
  • Holidays and Observances around the World More
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